Adenosine 2A Receptors and Epoxyeicosatrienoic Acids
نویسندگان
چکیده
منابع مشابه
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.
Adenosine, astrocyte metabotropic glutamate receptors (mGluRs), and epoxyeicosatrienoic acids (EETs) have been implicated in neurovascular coupling. Although A(2A) and A(2B) receptors mediate cerebral vasodilation to adenosine, the role of each receptor in the cerebral blood flow (CBF) response to neural activation remains to be fully elucidated. In addition, adenosine can amplify astrocyte cal...
متن کاملRed blood cells (RBCs), epoxyeicosatrienoic acids (EETs) and adenosine triphosphate (ATP).
In addition to serving as carriers of O(2), red blood cells (RBCs) regulate vascular resistance and the distribution of microvascular perfusion by liberating adenosine triphosphate (ATP) and epoxyeicosatrienoic acids (EETs) upon exposure to a low O(2) environment. Therefore, RBCs act as sensors that respond to low pO(2) by releasing millimolar amounts of ATP, a signaling molecule, and lipid med...
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Inflammation is a key element in many cardiovascular diseases. Both estrogen loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid. EETs are in the third (Cytochrome P450) pathway of arachindonic acid metabolism, others being cyclooxygenases ...
متن کاملEpoxyeicosatrienoic acids, hypertension, and kidney injury.
K idney disease afflicts 33 million in the United States, and chronic kidney disease (CKD) accounts for >$60 billion in Medicare costs. Hypertension afflicts 75 million in the United States, and significant portions of those patients develop CKD and progress to end-stage renal disease. Interestingly, resistant hypertension which is defined as uncontrolled hyperten-sion, despite 3 antihypertensi...
متن کاملAdenosine2A receptors and epoxyeicosatrienoic acids: a recipe for salt and blood pressure regulation.
Salt has been used as a food preservative and part of the human diet for thousands of years. Consequently, human dietary sodium chloride intake is significantly higher than that needed to sustain life. Fortunately, kidneys function to regulate sodium chloride excretion to maintain proper levels of sodium chloride and extracellular volume when dietary salt intake changes. If the kidneys are prop...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2009
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.109.129981